Crag keeps the light 'fantastic' for photoreceptors
The ability of the eye of a fruit fly (Drosophila melanogaster) to respond to light depends on a delicate ballet that keeps the supply of light sensors called rhodopsin constant as photoreceptors turn...
View ArticleResearchers highlight potential gene therapy approach to sickle cell disease
Researchers at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) have taken the first preliminary steps toward developing a form of gene therapy for sickle cell disease. In an abstract presented...
View ArticleResearchers find new culprit in castration-resistant prostate cancer
Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur...
View ArticleScientists reveal aggressive breast cancer's metastatic path
Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away...
View ArticleTeam identifies molecular switch enabling immune cells to better fight disease
A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting...
View ArticlePreclinical study identifies 'master' proto-oncogene that regulates ovarian...
Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins – known as Src – leads to ovarian cancer...
View ArticleNew study says molecular 'switch' may play role in tumor suppression
Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular...
View ArticleFlip of a single molecular switch makes an old brain young
The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now Yale School of...
View ArticleResearchers find molecular switch turning on self-renewal of liver damage
The liver is one of the few organs in our body that can regenerate itself, but how it occurs is a biological mystery. New research from BRIC, University of Copenhagen and the Finsen Laboratory,...
View ArticleNew genetic link found between normal fetal growth and cancer
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on...
View ArticleSource of tumor growth in aggressive prostate cancer found
Researchers have discovered a molecular switch that explains, at least in part, how some fast-growing prostate cancers become resistant to hormone treatment, a new study conducted in human cell...
View ArticleMolecular switch controls the destiny of self-eating cells
The study is the result of a collaboration of scientists at Karolinska Institutet in Sweden, University of Michigan, and University of California San Diego, USA, who were interested in finding out...
View ArticleHeading for regeneration
The rabbit can't do it, neither can a frog, but zebrafish and axolotls can and flatworms are true masters of the craft: Regeneration. Why some animals can re-grow lost body parts or organs while others...
View ArticleNew inhibitor blocks the oncogenic protein KRAS
One of the major goals in the development of anti-cancer treatments is to find an inhibitor effective against the oncogenic protein known as KRAS. Despite decades of active agent research, efforts to...
View ArticleStatins may slow human aging by protecting against telomere shortening: A...
Not only do statins extend lives by lowering cholesterol levels and reducing the risks of cardiovascular disease, but new research in the September 2013 issue of The FASEB Journal suggests that they...
View ArticleFragile X syndrome protein linked to breast cancer progression
A research team led by scientists from VIB/KU Leuven, Belgium, and the University of Rome Tor Vergata, Italy, in collaboration with several research centers and hospitals in Italy, the United Kingdom...
View ArticleNew knowledge on molecular mechanisms behind breast cancer
Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis. The research objective is improved and...
View ArticleBlood stem cells age at the unexpected flip of a molecular switch
Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age.
View ArticleTwo sides of a safety switch
Swiss researchers have discovered a new, surprising link between chloracne and a molecule that protects cells against stress: if Nrf2 gets out of control, disfiguring cysts form on the skin.
View ArticleGeneticists study how individual nerve cells assemble into specific nerves
(Medical Xpress)—Geneticists from Trinity College Dublin interested in 'reverse engineering' the nervous system have made an important discovery with wider implications for repairing missing or broken...
View ArticlePhotopharmacology: Optical control of insulin secretion
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have chemically modified an anti-diabetic agent so as to make its action dependent on light. The resulting prototype compound, termed...
View ArticlePurging a virus from organ transplants
Human cytomegalovirus (HCMV) is an extremely common virus, which as other members of the herpes virus family causes life-long infections in humans. Most individuals are exposed to HCMV during...
View ArticleA molecular switch to stop inflammation
Our immune system is vital to us and can sometimes overreact causing chronic illnesses, such as for instance rheumatism and allergy. Now, researchers from Umeå University and University of Gothenburg...
View ArticleHIV drug could stop skin cancer becoming drug-resistant
An HIV drug could stop one of the early changes in skin cancer cells that leads to them becoming resistant to treatment, according to a Cancer Research UK-funded study published in Cancer Cell today.
View ArticleNew life breathed into lung cancer study initiated 15 years ago
In the late 1990s, University of Kentucky Professor Douglas Andres found that mutations in a protein known as RIT1 could initiate cancer development in laboratory models.
View ArticleScientists flip molecular switches to distinguish related immune cells
The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic...
View ArticleHow head and neck squamous cell carcinomas take over wound-healing processes
A*STAR researchers have identified the molecular means by which a common form of cancer hijacks wound-healing processes to help it spread. The team hope their findings could lead to more effective...
View ArticleHidden genetic effects behind immune diseases may be missed, study suggests
The role of genetics in the risk of having an immune disease could be missed in research, scientists suggest. Using a combination of stem cells and novel analytical tools, scientists at the Wellcome...
View ArticleThe end of yo-yo dieting? Researchers uncover brain switch that controls fat...
Scientists have discovered a molecular switch in the brain that regulates fat burning - and could provide a way to control weight gain following dieting.
View ArticleNew targets revealed for the treatment of inflammatory conditions
Research by the University of Bristol has shed light on the way our clotting cells and immune cells control their interactions with each other.
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